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Receptor tyrosine kinases are a large family of cell-surface receptors that respond to a variety of intercellular signals, including insulin, growth factors such as epidermal growth factor (EGF) and fibroblast growth factor (FGF), and molecules involved in neuronal guidance. Ligand bindingstimulates the tyrosine kinase activity of the receptors, leading to recruitment of enzymes and adapter proteins that activate intracellular signaling pathways that control cell proliferation, differentiation, and numerous other biological processes.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology discusses the mechanisms underlying receptor tyrosine kinase signaling, including ligand processing, receptor dimerization, receptor trafficking, and the roles of adapters. The contributorsalso survey the specific functions of theReceptor tyrosine kinases are a large family of cell-surface receptors that respond to a variety of intercellular signals, including insulin, growth factors such as epidermal growth factor (EGF) and fibroblast growth factor (FGF), and molecules involved in neuronal guidance. Ligand
The articles in the present volume are by major contributors to our under- standing of signaling pathways affecting protein synthesis. They focus pri- marily on two extracellular anabolic signals, although others are included as well. Insulin is one of the best-studied extracellular regulators of
This volume aims to provide clear and detailed methods to probe glutamate receptor function. Chapters in this book feature methods to study synaptic ultrastructure, receptor dynamics/receptor interactions and trafficking, cellular plasticity, receptor gene regulation, epigenetics, and clinical
This fiftieth-anniversary edition commemorates Joseph Heller's masterpiece with a new introduction; critical essays and reviews by Norman Mailer, Alfred Kazin, Anthony Burgess, and others; rare papers and photos; and much more. Nominated as one of America's best-loved novels by PBS's The Great
Spirit, with Josephine Wall's celestial art is a remarkable evocation of mind, body and spirit, graced with poetry and quotations for readers of every age. Josephine is a popular artists with a huge following online. A new series of gift books from Flame Tree, Thoughts to Inspire & Motivate
O Josephine! features four new graphic short stories crafted with Jason's signature dry wit, deadpan humor, and elegantly minimalist style. The artist takes a meditative walk along the picturesque Wicklow Way in the Irish countryside. A paean to the life of the inimitable Leonard Cohen, with a few
Josephus, soldier, statesman, historian, was a Jew born at Jerusalem about 37 CE. A man of high descent, he early became learned in Jewish law and Greek literature and was a Pharisee. After pleading in Rome the cause of some Jewish priests he returned to Jerusalem and in 66 tried to prevent revolt
From the award winning poet Joseph Coelho comes a moving, lyrical picture book about a shy child unlocking the power of their own voice through
Josephus, soldier, statesman, historian, was a Jew born at Jerusalem about 37 CE. A man of high descent, he early became learned in Jewish law and Greek literature and was a Pharisee. After pleading in Rome the cause of some Jewish priests he returned to Jerusalem and in 66 tried to prevent revolt
Highly regarded and best-selling literary writer and teacher, Joseph Pearce presents a stimulating and vivid biography of the world's most revered writer that is sure to be controversial. Unabashedly provocative, with scholarship, insight and keen observation, Pearce strives to separate historical
The first monograph on one of today's most celebrated architects, renowned for designing interiors that combine minimalism with classic French style. When describing a space that intertwines both minimalism and elegance, the name Joseph Dirand immediately comes to mind. The son of Jacques Dirand,
Josephus, soldier, statesman, historian, was a Jew born at Jerusalem about 37 CE. A man of high descent, he early became learned in Jewish law and Greek literature and was a Pharisee. After pleading in Rome the cause of some Jewish priests he returned to Jerusalem and in 66 tried to prevent revolt
Meet Josephine, the most loveable mischief-maker in Barbados, in a magical, heartfelt adventure inspired by Caribbean mythology.Eleven-year-old Josephine knows that no one is good enough for her daddy. That's why she makes a habit of scaring his new girlfriends away. She's desperate to make it onto
Subject to passionate controversy during his lifetime, the work of Joseph Beuys is now considered one of the most significant and influential contributions to twentieth-century fine arts.The Essential Joseph Beuys locates the artist's oeuvre as he saw it: part of a larger, philosophically based
Josephus, soldier, statesman, historian, was a Jew born at Jerusalem about 37 CE. A man of high descent, he early became learned in Jewish law and Greek literature and was a Pharisee. After pleading in Rome the cause of some Jewish priests he returned to Jerusalem and in 66 tried to prevent revolt