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This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug.
Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical
This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an
This book provides state of the art information on the pathogenesis, diagnosis, and treatment of a range of inflammatory, autoimmune, and idiopathic neuromuscular disorders. The opening section discusses the differential diagnosis of acquired myopathies based on clinical, electrophysiological,
Master the diagnosis and effective treatment of veterinary neurologic disorders! de Lahunta's Veterinary Neuroanatomy and Clinical Neurology, 5th Edition provides in-depth coverage of the anatomy, physiology, and pathology of the nervous system. With this knowledge, you will be able to accurately
Through dozens of tables, illustrative figures, and real-life case examples, established experts in the field, as well as a new generation of scientists, examine clinical concepts; risk factors for and impact of personality disorders; treatment options (including a new chapter on early
Master the evaluation and treatment of swallowing disorders Dysphagia: Clinical Management in Adults and Children, 3rd Edition provides the information you need to diagnose and manage dysphagia in patients of all ages. Emphasizing evidence-based practice, this complete resource covers topics from
Base your care of neurological patients on evidence-based best practices, with the completely updated, fully illustrated The Clinical Practice of Neurological and Neurosurgical Nursing, 8th Edition. This is the most current and comprehensive neuroscience nursing text, written to support you in the
This third edition volume expands on the previous editions with new topics that cover drug discovery through translational bioinformatics, informatics, clinical research informatics, as well as clinical
Preface.- Part 1. Phenotypic features.- Classification of mood disorders. Developmental aspects of depression. Animal models of depression vulnerability. Genetic mouse models of depression.- Part 2. Cellular and Molecular Basis.- The Genetic basis of depression. Neurochemical Imaging and Depressive
Written by experts in geriatric psychiatryIdeal review book to study for the American Board of Psychiatry and Neurology, Geriatric Psychiatry and Neurology initial and re-certification examinations The only text on the market to include a comprehensive, current review of the
The field of feeding and eating disorders represents one of the most challenging areas in mental health, covering childhood, adolescent and adult manifestations of the disorders and requiring expertise in both the physical and psychological issues that can cause, maintain, and exacerbate these
Rectal Cancer: Modern Approaches to Treatment provides a useful overview of the multidisciplinary treatment of rectal cancer with a deeper dive into clinical challenges faced by treating
Neuroticism--the tendency to experience negative emotions, along with the perception that the world is filled with stressful, unmanageable challenges--is strongly associated with anxiety, depression, and other common mental health conditions. This groundbreaking volume shows how targeting this
Now completely revised (over 90% new), this definitive practitioner reference and course text comprehensively reviews evidence-based treatments for psychological disorders in children and adolescents. The significantly expanded fourth edition covers an increased number of disorders, as well as
This volume, the first of the two-volume Drug Delivery Approaches and Nanosystems series, presents a full picture of the state-of-the-art research and development in drug delivery systems using nanotechnology and its applications. It addresses the ever-expanding application of nanotechnology or
Assessment and Treatment of Muscle Imbalance: The Janda Approach blends postural techniques, neurology, and functional capabilities in order to alleviate chronic musculoskeletal pain and promote greater functionality. Developed by Vladimir Janda, respected neurologist and physiotherapist, the
A philosophical account of the structure of experience and how it depends on interpersonal relations, developed through a study of auditory verbal hallucinations and thought insertion.In Real Hallucinations, Matthew Ratcliffe offers a philosophical examination of the structure of human experience,
Dark dragons, ghostly bagpipers, rude goblins and sly wizards - discover the legends that dwell within the ancient castles of Scotland. This highly anticipated book is the latest volume of much-loved Scottish tale treasuries by Carnegie-award-winning children's author Theresa Breslin and Kate
From Jack the Ripper to the modern day drug cartels, discover the most notorious crimes and criminals in history.With a foreword by bestselling crime author Peter James, The Crime Book explores over 100 crimes and examines the science, psychology and sociology of criminal behaviour. See the gory
The Handbook of Religion and Society is the most comprehensive and up-to-date treatment of a vital force in the world today. It is an indispensable resource for scholars, students, policy makers, and other professionals seeking to understand the role of religion in society. This includes both the
Offers a perspective on how 4-manifold theory was studied before the discovery of modern-day Seiberg-Witten theory. This book predates Donaldson's applications of the subject to 4-manifold topology, where the central concern was the geometry of the moduli
Discover the stunning concept art and developer commentaries behind the latest game in the genre-defining Call of Duty: Modern Warfare
Epilepsy is one of the most familiar chronic neurological diseases and is a common yet challenging presentation in veterinary surgeries. This book covers seizure pathogenesis, classifications, diagnostic investigations, emergency treatments, and longer term treatments, with a large section on